St. John's Wort Mood Lift Tincture
Clinically proven for mild-to-moderate depression
Strong evidenceHerbs in this remedy
About this remedy
St. John's Wort is one of the most extensively studied herbal antidepressants. A Cochrane review of 29 trials involving over 5,400 patients concluded it is more effective than placebo and comparable to standard SSRIs for mild-to-moderate depression, with fewer side effects. Hyperforin, its primary active compound, modulates serotonin, dopamine, and noradrenaline reuptake — the same pathways targeted by pharmaceutical antidepressants.
Preparation
Take a standardized extract (0.3% hypericin) — typically 300 mg capsules, 3 times daily with meals. Or 2-4 ml of a 1:5 tincture, 3 times daily.
Dosage
Allow 4-6 weeks to judge full mood-lifting effect. Do not stop abruptly — taper over 1-2 weeks.
Cautions
Interacts with MANY medications including SSRIs, birth control pills, blood thinners, and HIV medications — check with a pharmacist or doctor before starting. May cause photosensitivity; use sun protection. Not for severe or suicidal depression.
Research
Linde et al., Cochrane Database Syst Rev, 2008 — St. John's wort for major depression